ASM Oral Presentation Australian Society for Microbiology Annual Scientific Meeting 2025

Trigger Factor in Burkholderia pseudomallei is essential for key virulence determinants including host cell internalisation, cytotoxicity, motility and stress resistance. (121181)

Justine B Bendo 1 , Aleksandra W Debowski 1 2 , Nicole M Bzdyl 1 3 , Jua Iwasaki 1 3 , Josephine Starr 1 , Nichollas E Scott 4 , Keith A Stubbs 2 , Mitali Sarkar-Tyson 1
  1. Marshall Centre for Infectious Diseases, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia
  2. School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia
  3. Wesfarmers Centre for Vaccines and Infectious Diseases, University of Western Australia, Nedlands, WA, Australia
  4. The Peter Doherty Institute for Infection and Immunity, Melbourne, Vic, Australia
Publish consent withheld
  1. Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ. Burkholderia pseudomallei and melioidosis. Nat. Rev. Microbiol. 2024;22(3):155-69.
  2. Smith S, Hanson J, Currie BJ. Melioidosis: An Australian perspective. Trop. Med. Infect. Dis. 2018;3(1).
  3. Bigot A, Botton E, Dubail I, Charbit A. A homolog of Bacillus subtilis trigger factor in Listeria monocytogenes is involved in stress tolerance and bacterial virulence. Appl. Environ. Microbiol. 2006;72(10):6623-31.
  4. Keogh RA, Zapf RL, Frey A, Marino EC, Null GG, Wiemels RE, et al. Staphylococcus aureus trigger factor is involved in biofilm formation and cooperates with the chaperone PpiB. J. Bacteriol. 2021;203(7): e00681-20
  5. Wen ZT, Suntharaligham P, Cvitkovitch DG, Burne RA. Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation. Infect. Immun. 2005;73(1):219-25.