ASM Poster Presentation Australian Society for Microbiology Annual Scientific Meeting 2025

Metabolic balancing of carbohydrate and lipid pathways regulates cell type transitioning in the human pathogen Candida albicans (#214)

Manasa Bharathwaj 1 , Maalavikha Prabhakaran 1 , Angavai Swaminathan 1 , Rachael Turner 1 , Yu Zhang 2 , Vinzenz Hofferek 3 , Malcolm J McConville 3 , Traude H Beilharz 1 , Gregory L Challis 1 2 , Ana Traven 1
  1. Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia
  2. Department of Chemistry, University of Warwick, Coventry, United Kingdom
  3. Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia
Publish consent withheld
  1. Sudbery, P. Growth of Candida albicans hyphae. Nat Rev Microbiol 9, 737–748 (2011). https://doi.org/10.1038/nrmicro2636
  2. Uppuluri P, Chaturvedi AK, Srinivasan A, et al. Dispersion as an important step in the Candida albicans biofilm developmental cycle. PLoS Pathog. 2010;6(3):e1000828. Published 2010 Mar 26. doi:10.1371/journal.ppat.1000828
  3. Song L, Jenner M, Masschelein J, et al. Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis. J Am Chem Soc. 2017;139(23):7974-7981. doi:10.1021/jacs.7b03382
  4. Simm C, Lee T-H, Weerasinghe H, et al. Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements. mBio. 2024;15(11):e0261124. doi:10.1128/mbio.02611-24
  5. Villa S, Hamideh M, Weinstock A, Qasim MN, Hazbun TR, Sellam A, Hernday AD, Thangamani S. Transcriptional control of hyphal morphogenesis in Candida albicans. FEMS Yeast Res. 2020 Feb 1;20(1):foaa005. doi: 10.1093/femsyr/foaa005. PMID: 31981355; PMCID: PMC7000152.