ASM Oral Presentation Australian Society for Microbiology Annual Scientific Meeting 2025

Overcoming Multidrug resistant Gram-negative Infections with Synergistic Combinations of Antibiotics and Octapeptin Lipopeptides (121224)

Michelle Novais de Paula 1 , Johannes Zuegg 1 , Alysha G Elliott 1 , Mark AT Blaskovich 1
  1. Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
Publish consent withheld
  1. O’Neill, J. Tackling drug-resistant infections globally: final report and recommendations. (Government of the United Kingdom, 2016).
  2. Becker, B. et al. Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorg Med Chem Lett 27, 2407-2409,j.bmcl.2017.04.027 (2017).
  3. Blaskovich, M. A. T., Pitt, M. E., Elliott, A. G. & Cooper, M. A. Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria? Expert Rev Anti Infect Ther 16, 485-499, doi:10.1080/14787210.2018.1483240 (2018).
  4. Velkov, T. et al. Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chem Biol 25, 380-391.e385, j.chembiol.2018.01.005 (2018).